Synthesis of substituted benzimidazolyl curcumin mimics and their anticancer activity

Title
Synthesis of substituted benzimidazolyl curcumin mimics and their anticancer activity
Authors
우호범염영우박규상함정엽안찬묵이석준
Keywords
Synthesis; Curcumin mimics; Natural product; Anticancer; Aldol reaction
Issue Date
2012-01
Publisher
Bioorganic & medicinal chemistry letters
Citation
VOL 22, NO 2, 933-936
Abstract
A novel curcumin mimic library (14a–14h and 15a–15h) possessing variously substituted benzimidazole groups was synthesized through the aldol reaction of (E)-4-(4-hydroxy-3-methoxyphenyl)but-3-en-2- one (7) or (E)-4-(3-hydroxy-4-methoxyphenyl)but-3-en-2-one (13) with diversely substituted benzimidazolyl- 2-carbaldehyde (12a–12h). The MTT assay of the cancer cells MCF-7, SH-SY5Y, HEP-G2, and H460 showed that compound 14c with IC50 of 1.0 and 1.9 lM has a strong inhibitory effect on the growth of SH-SY5Y and Hep-G2 cells, respectively, and that compound 15h with IC50 of 1.9 lM has a strong inhibitory effect on the growth of MCF-7 cancer cells.
URI
http://pubs.kist.re.kr/handle/201004/42141
ISSN
0960894X
Appears in Collections:
KIST Publication > Article
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