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dc.contributor.author우호범-
dc.contributor.author염영우-
dc.contributor.author박규상-
dc.contributor.author함정엽-
dc.contributor.author안찬묵-
dc.contributor.author이석준-
dc.date.accessioned2015-12-03T00:46:45Z-
dc.date.available2015-12-03T00:46:45Z-
dc.date.issued201201-
dc.identifier.citationVOL 22, NO 2, 933-936-
dc.identifier.issn0960894X-
dc.identifier.other36984-
dc.identifier.urihttp://pubs.kist.re.kr/handle/201004/42141-
dc.description.abstractA novel curcumin mimic library (14a–14h and 15a–15h) possessing variously substituted benzimidazole groups was synthesized through the aldol reaction of (E)-4-(4-hydroxy-3-methoxyphenyl)but-3-en-2- one (7) or (E)-4-(3-hydroxy-4-methoxyphenyl)but-3-en-2-one (13) with diversely substituted benzimidazolyl- 2-carbaldehyde (12a–12h). The MTT assay of the cancer cells MCF-7, SH-SY5Y, HEP-G2, and H460 showed that compound 14c with IC50 of 1.0 and 1.9 lM has a strong inhibitory effect on the growth of SH-SY5Y and Hep-G2 cells, respectively, and that compound 15h with IC50 of 1.9 lM has a strong inhibitory effect on the growth of MCF-7 cancer cells.-
dc.publisherBioorganic & medicinal chemistry letters-
dc.subjectSynthesis-
dc.subjectCurcumin mimics-
dc.subjectNatural product-
dc.subjectAnticancer-
dc.subjectAldol reaction-
dc.titleSynthesis of substituted benzimidazolyl curcumin mimics and their anticancer activity-
dc.typeArticle-
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