Tentative identification of phase I metabolites of HU-210, a classical synthetic cannabinoid, by LC-MS/MS
- Tentative identification of phase I metabolites of HU-210, a classical synthetic cannabinoid, by LC-MS/MS
- 김운용; 김명길; 이재익; 한상범; 인문교; 유혜현
- HU-210; Synthetic cannabinoid; Metabolism; LC-MS/MS
- Issue Date
- Journal of pharmaceutical and biomedical analysis
- VOL 64-65, 26-34
c]chromen-1-ol (HU-210) is a synthetic cannabinoid, with a classical cannabinoid
structure similar to 9-tetrahydrocannabinol (Δ9-THC). In this study, the in vitro metabolism of HU-210
was investigated in human liver microsomes to characterize associated phase I metabolites. HU-210
was incubated with human liver microsomes, and the reaction mixture was analyzed using LC–MS/MS.
HU-210 was metabolized in human liver microsomes, yielding about 24 metabolites. These metabolites
were structurally characterized on the basis of accurate mass analyses and MS/MS fragmentation patterns.
The major metabolic route for HU-210 was oxygenation. Metabolites M1–M7 were identified as
mono-oxygenated metabolites; M8–M15, mono-hydroxylated metabolites; M16–M20, di-oxygenated
metabolites; and M21–M24, di-hydroxylated metabolites. These results provide evidence for in vivo
HU-210 metabolism, and they may be applied to the analysis of HU-210 and its relevant metabolites in
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