α- and γ-Mangostin inhibit the proliferation of colon cancer cells via β-catenin gene regulation in Wnt/cGMP signalling

Title
α- and γ-Mangostin inhibit the proliferation of colon cancer cells via β-catenin gene regulation in Wnt/cGMP signalling
Authors
유지혜강경수조은혜진용원김진웅노주원
Keywords
Mangostins; β-Catenin; Transcriptional regulation; cGMP; PKG
Issue Date
2011-11
Publisher
Food chemistry
Citation
VOL 129, NO 4, 1559-1566
Abstract
Aberrant activation of Wnt/b-catenin signalling via genetic errors within β-catenin or APC has a crucial role in carcinogenesis. Here, we studied two xanthones, a- and c-mangostin, as inhibitors of Wnt/β-catenin signalling. The mangostins inhibited TCF/β-catenin transcriptional activity. The mangostins also inhibited protein expression of β-catenin in colon cancer cells, but the inhibition was independent of the phosphorylation and degradation of β-catenin. Instead, the mangostins increased the levels of cGMP and cGMP-dependent kinase, indicating that the inhibition of β-catenin resulted from b-catenin gene regulation. Our results indicate that mangostins could be potential candidates for preventing colon cancer through a novel mechanism of inhibiting Wnt/b-catenin signalling.
URI
http://pubs.kist.re.kr/handle/201004/42204
ISSN
0308-8146
Appears in Collections:
KIST Publication > Article
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE