α- and γ-Mangostin inhibit the proliferation of colon cancer cells via β-catenin gene regulation in Wnt/cGMP signalling
- α- and γ-Mangostin inhibit the proliferation of colon cancer cells via β-catenin gene regulation in Wnt/cGMP signalling
- 유지혜; 강경수; 조은혜; 진용원; 김진웅; 노주원
- Mangostins; β-Catenin; Transcriptional regulation; cGMP; PKG
- Issue Date
- Food chemistry
- VOL 129, NO 4, 1559-1566
- Aberrant activation of Wnt/b-catenin signalling via genetic errors within β-catenin or APC has a crucial
role in carcinogenesis. Here, we studied two xanthones, a- and c-mangostin, as inhibitors of Wnt/β-catenin
signalling. The mangostins inhibited TCF/β-catenin transcriptional activity. The mangostins also
inhibited protein expression of β-catenin in colon cancer cells, but the inhibition was independent of
the phosphorylation and degradation of β-catenin. Instead, the mangostins increased the levels of cGMP
and cGMP-dependent kinase, indicating that the inhibition of β-catenin resulted from b-catenin gene regulation.
Our results indicate that mangostins could be potential candidates for preventing colon cancer
through a novel mechanism of inhibiting Wnt/b-catenin signalling.
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