Schisandrin B suppresses TGFβ1 signaling by inhibiting Smad2/3 and MAPK pathways
- Schisandrin B suppresses TGFβ1 signaling by inhibiting Smad2/3 and MAPK pathways
- 박은정; 전정녀; 김수화; 김철영; 이희주; 김혜경; 박종관; 이성원; 소인숙; 전주홍
- Schisandra chinensis; Schisandrin B; TGFβ1; Vascular smooth muscle cell; Vascular fibrotic disease
- Issue Date
- Biochemical pharmacology
- VOL 83, NO 3, 378-384
- TGFβ1 plays a crucial role in the pathogenesis of vascular fibrotic diseases. Schisandra chinensis (S.
chinensis), which is used as an oriental herbal medicine, is effective in the treatment of vascular injuries
that cause aberrant TGFβ1 signaling. In this study, we investigated whether S. chinensis extract and its
active ingredients inhibit TGFβ1 signaling in A7r5 vascular smooth muscle cells. We found that S.
chinensis extract suppressed TGFβ1 signaling via inhibition of Smad2/3 phosphorylation and nuclear
translocation. Among the active ingredients of S. chinensis extract, schisandrin B (SchB) most potently
inhibited TGFβ1 signaling. SchB inhibited sustained phosphorylation and nuclear translocation of
Smad2/3. Moreover, SchB suppressed TGFβ1-induced phosphorylation of p38 and JNK, which
contributed to Smad2/3 inactivation. The present study is the first to demonstrate that S. chinensis
extract and SchB inhibit TGFβ1 signaling. Our results may help future investigations to understand
vascular fibrosis pathogenesis and to develop novel therapeutic strategies for treatment of vascular
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