Schisandrin B suppresses TGFβ1 signaling by inhibiting Smad2/3 and MAPK pathways

Title
Schisandrin B suppresses TGFβ1 signaling by inhibiting Smad2/3 and MAPK pathways
Authors
박은정전정녀김수화김철영이희주김혜경박종관이성원소인숙전주홍
Keywords
Schisandra chinensis; Schisandrin B; TGFβ1; Vascular smooth muscle cell; Vascular fibrotic disease
Issue Date
2012-02
Publisher
Biochemical pharmacology
Citation
VOL 83, NO 3, 378-384
Abstract
TGFβ1 plays a crucial role in the pathogenesis of vascular fibrotic diseases. Schisandra chinensis (S. chinensis), which is used as an oriental herbal medicine, is effective in the treatment of vascular injuries that cause aberrant TGFβ1 signaling. In this study, we investigated whether S. chinensis extract and its active ingredients inhibit TGFβ1 signaling in A7r5 vascular smooth muscle cells. We found that S. chinensis extract suppressed TGFβ1 signaling via inhibition of Smad2/3 phosphorylation and nuclear translocation. Among the active ingredients of S. chinensis extract, schisandrin B (SchB) most potently inhibited TGFβ1 signaling. SchB inhibited sustained phosphorylation and nuclear translocation of Smad2/3. Moreover, SchB suppressed TGFβ1-induced phosphorylation of p38 and JNK, which contributed to Smad2/3 inactivation. The present study is the first to demonstrate that S. chinensis extract and SchB inhibit TGFβ1 signaling. Our results may help future investigations to understand vascular fibrosis pathogenesis and to develop novel therapeutic strategies for treatment of vascular fibrotic diseases.
URI
http://pubs.kist.re.kr/handle/201004/42248
ISSN
00062952
Appears in Collections:
KIST Publication > Article
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