Synthesis of PEO-Based Glucose-Sensitive Block Copolymers and Their Application for Preparation of Superparamagnetic Iron Oxide Nanoparticles

Title
Synthesis of PEO-Based Glucose-Sensitive Block Copolymers and Their Application for Preparation of Superparamagnetic Iron Oxide Nanoparticles
Authors
이상미남주현김유진조영준권난현이재열강호중김훈태박흥목김세훈김정안
Keywords
pH- and glucose-responsive block copolymer; RAFT polymerization, ring-opening polymerization; xanthate-type agent; ARS complex; water-soluble iron oxide nanoparticles
Issue Date
2011-08
Publisher
Macromolecular research
Citation
VOL 19, NO 8, 827-834
Abstract
Amphiphilic block copolymers were synthesized by reversible addition fragmentation chain transfer (RAFT) radical block polymerization of N-vinylimidazole and 3-(methacrylamido)phenylboronic acid using poly (ethylene oxide) (PEO)-based xanthate type of RAFT agent and 2,2′-azobisisobutyronitrile (AIBN) in dimethylformaide (DMF) at 90~110 ℃ for 24 h. Poly(ethylene oxide-b-3-(methacrylamido)phenylboronic acid) and poly(ethylene oxide-b-N-vinylimidazole-b-3-(methacrylamido)phenylboronic acid) were prepared successfully through the sequential monomer addition method. Both block copolymers were found to exhibit glucose-responsive behavior via the feasibility test for complex formation with Alizarin Red S (ARS). The ratio of molecular weight of the poly(N-vinyimidazole) to the poly(3-(methacrylamido)phenylboronic acid) appeared to play an important role in the pH- & glucose- responsive behavior. The resulting block copolymers were used successfully as polymeric stabilizers to prepare water-soluble Fe3O4 nanoparticles. All the materials were characterized by the combination of 1H nuclear magnetic resonance (NMR), size exclusion chromatography (SEC), transmission electron microscopy (TEM), thermogravimetric analysis (TGA), and x-ray diffraction (XRD) analyses.
URI
http://pubs.kist.re.kr/handle/201004/42251
ISSN
1598-5032
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KIST Publication > Article
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