Synthesis and Biological Evaluation of 1-Heteroarylmethyl 1,4-Diazepanes Derivatives as Potential T-type Calcium Channel Blockers

Title
Synthesis and Biological Evaluation of 1-Heteroarylmethyl 1,4-Diazepanes Derivatives as Potential T-type Calcium Channel Blockers
Authors
푸나구수진최연희박지연한소엽백두종이재균배애님민선준조용서
Keywords
T-type calcium channel blockers; 1,4-Diazepanes; Heteroaromatic compounds; FDSS6000 assay; Patch-clamp assay
Issue Date
2011-08
Publisher
Bulletin of the Korean Chemical Society
Citation
VOL 32, NO 8, 3063-3073
Abstract
The synthesis and biological evaluation of 1-heteroarylmethyl 1,4-diazepane derivatives as potential T-type calcium channel blockers is described. In this study, we have identified the compound 21i exhibiting the most potent T-type calcium channel blocking activity with IC50 value of 0.20 μM, which is superior to that of mibefradil.
URI
http://pubs.kist.re.kr/handle/201004/42252
ISSN
0253-2964
Appears in Collections:
KIST Publication > Article
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