Protopine reduces the inflammatory activity of lipopolysaccharide-stimulated murine macrophages

Title
Protopine reduces the inflammatory activity of lipopolysaccharide-stimulated murine macrophages
Authors
배덕성김영훈판철호노주원Javan SamdanJamyansan Yansan이재권
Keywords
Cyclooxygenase-2; Cytokine; Inflammation; Macrophage; Nitric oxide; Protopine
Issue Date
2012-02
Publisher
BMB REPORTS
Citation
VOL 45, NO 2, 108-113
Abstract
Protopine is an isoquinoline alkaloid contained in plants in northeast Asia. In this study, we investigated whether protopine derived from Hypecoum erectum L could suppress lipopolysaccharide (LPS)-induced inflammatory responses in murine macrophages (Raw 264.7 cells). Protopine was found to reduce nitric oxide (NO), cyclooxygenase-2 (COX-2), and prostaglandin E2 (PGE2) production by LPS-stimulated Raw 264.7 cells, without a cytotoxic effect. Pre-treatment of Raw 264.7 cells with protopine reduced the production of pro-inflammatory cytokines. These inhibitory effects were caused by blocking phosphorylation of mitogen-activated protein kinases (MAP kinases) and also blocking activation of a nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB).
URI
http://pubs.kist.re.kr/handle/201004/42257
ISSN
19766696
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KIST Publication > Article
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