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dc.contributor.author배덕성-
dc.contributor.author김영훈-
dc.contributor.author판철호-
dc.contributor.author노주원-
dc.contributor.authorJavan Samdan-
dc.contributor.authorJamyansan Yansan-
dc.contributor.author이재권-
dc.date.accessioned2015-12-03T00:47:16Z-
dc.date.available2015-12-03T00:47:16Z-
dc.date.issued201202-
dc.identifier.citationVOL 45, NO 2, 108-113-
dc.identifier.issn19766696-
dc.identifier.other37093-
dc.identifier.urihttp://pubs.kist.re.kr/handle/201004/42257-
dc.description.abstractProtopine is an isoquinoline alkaloid contained in plants in northeast Asia. In this study, we investigated whether protopine derived from Hypecoum erectum L could suppress lipopolysaccharide (LPS)-induced inflammatory responses in murine macrophages (Raw 264.7 cells). Protopine was found to reduce nitric oxide (NO), cyclooxygenase-2 (COX-2), and prostaglandin E2 (PGE2) production by LPS-stimulated Raw 264.7 cells, without a cytotoxic effect. Pre-treatment of Raw 264.7 cells with protopine reduced the production of pro-inflammatory cytokines. These inhibitory effects were caused by blocking phosphorylation of mitogen-activated protein kinases (MAP kinases) and also blocking activation of a nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB).-
dc.publisherBMB REPORTS-
dc.subjectCyclooxygenase-2-
dc.subjectCytokine-
dc.subjectInflammation-
dc.subjectMacrophage-
dc.subjectNitric oxide-
dc.subjectProtopine-
dc.titleProtopine reduces the inflammatory activity of lipopolysaccharide-stimulated murine macrophages-
dc.typeArticle-
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