Neuroprotective Effect of 3,6-disubstituted -pyrones from a marine Nocardiopsis sp.
- Neuroprotective Effect of 3,6-disubstituted -pyrones from a marine Nocardiopsis sp.
- 김민철; 권오욱; 박정배; 박진수; 김선여; 권학철
- 박테리아; 미생물; 신경보호; 신물질
- Issue Date
- 대한약학회 춘계 총회 및 학술 강연
- , 418-419
- Nocardiopsis is belong to actinomycetes and discovered from various environments, for example
Nocardiopsis was isolated from saline soil, marine sediment, salterns, honeybee guts and marine sponge.
Furthermore, Nocardiopsis are known as prolific bioresource for novel chemically interesting secondary
metabolites were isolated such as, pendolmycin, lucentamycins A-D, nocardiopsins A and B, fijiolides A
and B, nocazins A-C. In addition, secondary metabolite isolated Nocardiopsis exhibit various biological
activities, such as inhibition of TNF-induced NF B activation, cytotoxicity against HeLa cells, inhibition
of protein kinase C, and a saturosporin-like inhibition of cyclic AMP-dependent protein kinase. Our
ongoing study for bioactive secondary metabolites from marine microbial, as the results three new 3,6-
disubstituted -pyrone compounds isolated from a marine actinomycete Nocardiopsis sp. KMF-001. The
structures were determined on the basis of UV, NMR and HRFABMS data. Compound 1 possesses
significant neuroprotective effect on LPS-induced neurotoxicity of microglia cells.
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