Neuroprotective Effect of 3,6-disubstituted -pyrones from a marine Nocardiopsis sp. KMF-001

Title
Neuroprotective Effect of 3,6-disubstituted -pyrones from a marine Nocardiopsis sp. KMF-001
Authors
김민철권오욱박정배박진수김선여권학철
Keywords
박테리아; 미생물; 신경보호; 신물질
Issue Date
2012-04
Publisher
대한약학회 춘계 총회 및 학술 강연
Citation
, 418-419
Abstract
Nocardiopsis is belong to actinomycetes and discovered from various environments, for example Nocardiopsis was isolated from saline soil, marine sediment, salterns, honeybee guts and marine sponge. Furthermore, Nocardiopsis are known as prolific bioresource for novel chemically interesting secondary metabolites were isolated such as, pendolmycin, lucentamycins A-D, nocardiopsins A and B, fijiolides A and B, nocazins A-C. In addition, secondary metabolite isolated Nocardiopsis exhibit various biological activities, such as inhibition of TNF-induced NF B activation, cytotoxicity against HeLa cells, inhibition of protein kinase C, and a saturosporin-like inhibition of cyclic AMP-dependent protein kinase. Our ongoing study for bioactive secondary metabolites from marine microbial, as the results three new 3,6- disubstituted -pyrone compounds isolated from a marine actinomycete Nocardiopsis sp. KMF-001. The structures were determined on the basis of UV, NMR and HRFABMS data. Compound 1 possesses significant neuroprotective effect on LPS-induced neurotoxicity of microglia cells.
URI
http://pubs.kist.re.kr/handle/201004/42313
Appears in Collections:
KIST Publication > Conference Paper
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