Bone Formation Within the Vicinity of Biodegradable Magnesium Alloy Implant in a Rat Femur Model

Title
Bone Formation Within the Vicinity of Biodegradable Magnesium Alloy Implant in a Rat Femur Model
Authors
한형섭김영율김유찬조성윤차필령석현광양석조
Keywords
biomaterials; casting; mechanical properties; bone; compression test
Issue Date
2012-04
Publisher
Metals and Materials International
Citation
VOL 18, NO 2, 243-247
Abstract
The purposes of this preliminary study were to investigate the effect of increased Ca contents (5-10 wt% Ca) in Mg-Ca alloy on the mechanical properties and osseous healing rate in a standard rat defect model. Mechanical tests were performed using a compression system followed by qualitative histological analysis using the hemotoxylin and eosin (H&E) staining method and quantitative reverse transcriptase polymerase chain reaction (reverse transcriptase PCR). Mg-Ca alloy degraded fast in vivo while displaying a high level of the bone formation markersOC and ALP. Favorablemechanical strength properties were displayed as Ca content increased from 5 wt% to 10 wt% to show its potential to be considered as a load bearing implant material. The resultfrom this study suggests that the developed Mg-Ca alloy has the potential to serve as a biocompatible load bearing implant material that is degradable and possibly osteoconductive.
URI
http://pubs.kist.re.kr/handle/201004/42374
ISSN
15989623
Appears in Collections:
KIST Publication > Article
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE