Bone Formation Within the Vicinity of Biodegradable Magnesium Alloy Implant in a Rat Femur Model
- Bone Formation Within the Vicinity of Biodegradable Magnesium Alloy Implant in a Rat Femur Model
- 한형섭; 김영율; 김유찬; 조성윤; 차필령; 석현광; 양석조
- biomaterials; casting; mechanical properties; bone; compression test
- Issue Date
- Metals and Materials International
- VOL 18, NO 2, 243-247
- The purposes of this preliminary study were to investigate the effect of increased Ca contents (5-10 wt%
Ca) in Mg-Ca alloy on the mechanical properties and osseous healing rate in a standard rat defect model.
Mechanical tests were performed using a compression system followed by qualitative histological analysis
using the hemotoxylin and eosin (H&E) staining method and quantitative reverse transcriptase polymerase
chain reaction (reverse transcriptase PCR). Mg-Ca alloy degraded fast in vivo while displaying a high
level of the bone formation markersOC and ALP. Favorablemechanical strength properties were displayed
as Ca content increased from 5 wt% to 10 wt% to show its potential to be considered as a load bearing
implant material. The resultfrom this study suggests that the developed Mg-Ca alloy has the potential to
serve as a biocompatible load bearing implant material that is degradable and possibly osteoconductive.
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