A regioselective synthesis of multi-substituted 2-imino-1,3-oxazolines by one-pot reaction
- A regioselective synthesis of multi-substituted 2-imino-1,3-oxazolines by one-pot reaction
- 한민수; 한호규
- 2-Imino-1,3-oxazoline; α-Hydroxyketones; Carbodiimide; Heterocycles
- Issue Date
- Bulletin of the Korean Chemical Society
- VOL 33, NO 4, 1371-1374
- Heterocycles are significant chemical entities for research
on small molecule drugs and their development in the
pharmaceutical industry. Attention until now has focused on
synthetic methods for forming heterocycles. However, new
and efficient synthetic methods for the construction of
heterocyclic molecules are now being researched continuously.
In our previous papers, we reported the construction
of two different combinatorial libraries, including novel 2-
imino-1,3-thiazolines 1, that show T-type calcium channel
inhibitory activity1 and fungicidal property.2 Recently, a
number of reports examined the significant biological
activities of the 2-imino-1,3-thiazoline derivatives.3 As an
extension of our efforts to investigate the biological activities
of their analogues, we synthesized 2-imino-1,3-oxazolines 2,
which are isosteres of 2-imino-1,3-thiazolines 1 (Figure 1).
In the present study we investigate a method for synthesizing
multi-substituted 2-imino-1,3-oxazolines 2 with the
aim of increasing the diversity in chemical structures. A
comparison of the biological activity of 1 and 2 promises to
increase our understanding of the structure-activity relationship
of this series.
- Appears in Collections:
- KIST Publication > Article
- Files in This Item:
There are no files associated with this item.
- RIS (EndNote)
- XLS (Excel)
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.