Quantitative monitoring of corticosteroids in cosmetic products manufactured in Korea using LC-MS/MS

Title
Quantitative monitoring of corticosteroids in cosmetic products manufactured in Korea using LC-MS/MS
Authors
남윤식권일근이연희이강봉
Keywords
forensic science; prednisolone; hydrocortisone; betamethasone; dexamethasone; triamcinolone acetonide; LC-MS/MS; cosmetic products
Issue Date
2012-07
Publisher
Forensic science international
Citation
VOL 220, e23-e28
Abstract
Some cosmetic products manufactured in Korea for the treatment of eczema, seborrhea and psoriasis have been suspected to contain anti-inflammatory corticosteroids such as prednisolone, hydrocortisone, betamethasone, dexamethasone and triamcinolone acetonide without these ingredients being indicated on the label. Due to their severe side effects such as permenent skin atopy, these corticosteroids have to be monitored in cosmetic products from a forensic point of view. Many cosmetic product samples (N = 65) have been collected from both local and online markets in Korea. The corticosteroid content of these samples was analyzed by LC–MS/MS with diagnostic ions (m/z). Linearity was studied with 0.1–10 μg/mL range in all corticosteroids. Good correlation coefficients (r2 ≥ 0.997) were found and the limits of quantification were 4.68–7.97 ng/mL for each of the corticosteroids. At three different concentrations spanning the linear dynamic ranges, mean recoveries were 97.2–113.5%and precisions (RSD) for intra-day and inter-day analysis were less than 8.9%. Also, accuracy (Bias %) was less than 11.8%. The results showed that between 0.76–0.94 μg/g levels of prednisolone were detected in four cosmetic products and triamcinolone acetonidewas detected with a concentration in the range of 11.5–272 μg/g in nine samples. This fact reveals that some manufacturers have arbitrarily added these corticosteroids in their cosmetic products without indicating them on the label. Thus, these cosmetic products have to be monitored and if proven illegal preparations removed from the market.
URI
http://pubs.kist.re.kr/handle/201004/42680
ISSN
03790738
Appears in Collections:
KIST Publication > Article
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE