SYNTHESIS AND ANTIMICROBIALACTIVITY EVALUATION OF NEW OXAZOLIDINONE DERIVATIVES
- SYNTHESIS AND ANTIMICROBIALACTIVITY EVALUATION OF NEW OXAZOLIDINONE DERIVATIVES
- 디팍; 강순방; 배애님; 금교창
- Issue Date
- 대한화학회 춘계 학술대회
- VOL 107, P-283
- The increasing use of antimicrobials has resulted in many pathogens developing resistance to the existing
powerful drugs. Consequently, there is a pressing need to develop new antibiotics to keep place with
bacterial resistance. This 38-year innovation gap ended in 2000 with the introduction of linezolid
( marketed under the tradename Zyvox). Linezolid represents a new chemical class ofoxazolidinonecontaining
antibacterials. Novel antibacterial oxazolidinones were synthesized and their in vitro
antibacterial activities were evaluated. Most of the synthesized oxazolidinones showed good antibacterial
activity against the Gram-positive and Gram–negative bacteria tested.
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