SYNTHESIS AND ANTIMICROBIALACTIVITY EVALUATION OF NEW OXAZOLIDINONE DERIVATIVES

Title
SYNTHESIS AND ANTIMICROBIALACTIVITY EVALUATION OF NEW OXAZOLIDINONE DERIVATIVES
Authors
디팍강순방배애님금교창
Issue Date
2011-04
Publisher
대한화학회 춘계 학술대회
Citation
VOL 107, P-283
Abstract
The increasing use of antimicrobials has resulted in many pathogens developing resistance to the existing powerful drugs. Consequently, there is a pressing need to develop new antibiotics to keep place with bacterial resistance. This 38-year innovation gap ended in 2000 with the introduction of linezolid ( marketed under the tradename Zyvox). Linezolid represents a new chemical class ofoxazolidinonecontaining antibacterials. Novel antibacterial oxazolidinones were synthesized and their in vitro antibacterial activities were evaluated. Most of the synthesized oxazolidinones showed good antibacterial activity against the Gram-positive and Gram–negative bacteria tested.
URI
http://pubs.kist.re.kr/handle/201004/42765
Appears in Collections:
KIST Publication > Conference Paper
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