The serotonin-6 receptor as a novel therapeutic target

Title
The serotonin-6 receptor as a novel therapeutic target
Authors
윤형문임혜원
Keywords
depression; Alzheimer; cognitive disorders; Fyn; Jab1; ST1936
Issue Date
2011-12
Publisher
Experimental Neurobiology
Citation
VOL 20, NO 4, 159-168
Abstract
Serotonin (5-hydroxytryptamine, 5-HT) is an important neurotransmitter that is found in both the central and peripheral nervous systems. 5-HT mediates its diverse physiological responses through 7 different 5-HT receptor families: 5-HT1, 5-HT2, 5-HT3, 5-HT4, 5-HT5, 5-HT6, and 5-HT7 receptors. Among them, the 5-HT6 receptor (5-HT6R) is the most recently cloned serotonin receptor and plays important roles in the central nervous system (CNS) and in the etiology of neurological diseases. Compared to other 5-HT receptors, the 5-HT6R has been considered as an attractive CNS therapeutic target because it is expressed exclusively in the CNS and has no known isoforms. This review evaluates in detail the role of the 5-HT6R in the physiology and pathophysiology of the CNS and the potential usefulness of 5-HT6R ligands in the development of therapeutic strategies for the treatment of CNS disorders. Preclinical studies provide support for the use of 5-HT6R ligands as promising medications to treat the cognitive dysfunction associated with Alzheimer’s disease, obesity, depression, and anxiety.
URI
http://pubs.kist.re.kr/handle/201004/42777
ISSN
12262560
Appears in Collections:
KIST Publication > Article
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