Development, Optimization and Absorption Mechanism of DHP107, Oral Paclitaxel Formulation for Single-Agent Anticancer Therapy

Title
Development, Optimization and Absorption Mechanism of DHP107, Oral Paclitaxel Formulation for Single-Agent Anticancer Therapy
Authors
이인현홍정완장유라박영택정혜선
Keywords
paclitaxel; oral anticancer drug; single-agent; stomach cancer
Issue Date
2012-04
Publisher
New advances in The basic and clinical gastroenterology
Citation
, 357-374
Abstract
In conclusion, we prepared oral paclitaxel formulations that do not contain P-glycoprotein inhibitors as active pharmaceutical ingredients. The formulations are liquid at body temperature and can solubilize paclitaxel effectively. The oral bioavailability of paclitaxel was 14 ~ 20 % when compared to the intravenous Taxol formulation without concomitant administration of P-glycoprotein inhibitors. Preclinical efficacy study on mice showed that the tumor size was reduced significantly for the human non-small cell lung carcinoma. In separate studies, we have determined the tissue distribution of paclitaxel after oral administration (manuscript in preparation) and performed pre-clinical antitumor efficacy studies in mice with several tumor types (manuscript in preparation). Regulatory preclinical experiments to initiate the clinical evaluations of DHP107 have also been carried out.
URI
http://pubs.kist.re.kr/handle/201004/42921
ISSN
97895351
Appears in Collections:
KIST Publication > ETC
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE