Possible usage of poluphenolic compounds from green tea as anticancer supplement agents

Title
Possible usage of poluphenolic compounds from green tea as anticancer supplement agents
Authors
이지환이우정이승용Noriko Yamabe김수남조은주김현영강기성
Keywords
Green tea; Anticancer effect; Polyphenol; Tea catechin; Nephrotoxicity; Oxidative stress
Issue Date
2012-07
Publisher
Cancer Prevention Research (대한암예방학회지)
Citation
VOL 17, NO 2, 151-156
Abstract
In the present study, in vitro beneficial effects of tea catechins on gastrointestinal cancer as well as nephrotoxicity were explored. Antioxidant activities of 6 green tea catechins were evaluated by 1,1- diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity test. To evaluate the anticancer effect, the effect of (-)-epigallocatechin-3-gallate (EGCG) as a representative tea catechin was investigated in HCT-116 human colorectal cancer and AGS human gastric cancer cells. Protective effect of EGCG against oxidative renal cell damage was measured using radical generator, 2,2'-azobis (2-amidinopropane) dihydrochloride in LLC-PK1 cells. EGCG showed the strongest DPPH radical scavenging activity and completely decreased the gastrointestinal cancer cell viability at 10 μM. Moreover, EGCG protected renal epithelial LLC-PK1 cells from oxidative damage in the dose-dependent manner. Therefore, EGCG has beneficial effects on cancer therapy by its anticancer effect and by reducing oxidative stress-induced nephrotoxicity.
URI
http://pubs.kist.re.kr/handle/201004/42931
ISSN
17388015
Appears in Collections:
KIST Publication > Article
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