Steroid ionization technology I: Metal ion coordination ionspray technology for ionization of steroids

Title
Steroid ionization technology I: Metal ion coordination ionspray technology for ionization of steroids
Authors
김소희차은주김호준손정현박주형허영란윤은영권오승이재익
Issue Date
2012-08
Publisher
한국질량분석학회 2012여름정기학회
Abstract
Anabolic steroids are synthetic derivatives of the male hormone, and widely used to boost the athletic performance in sports. The detection of steroids has generally been performed by gas chromatography-mass spectrometry (GC-MS), but liquid chromatography-tandem mass spectrometry (LC-MS/MS) is gradually becoming more important. However, their ionization by common API ion source such as electrospray ionization (ESI), atmospheric pressure chemical ionization (APCI) and atmospheric pressure photo ionization (APPI) presents some difficulties due to the lack of acidic or basic group in their structure. Moreover, these methods have a limitation that all the steroids cannot be simultaneously ionized in single ionization source. Therefore, in the present study we introduce the metal ion coordination ionspray technology for effective ionization and sensitivity of anabolic steroids in LC-MS/MS and optimize MS parameters, organic modifiers, and concentration of metal ion for the best ionization and sensitivity of steroids. 
URI
http://pubs.kist.re.kr/handle/201004/42966
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KIST Publication > Conference Paper
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