Steroid ionization technology II: GC-APCI/Q/ToF MS (APGC/HRMS) technology for ionization of steroids

Title
Steroid ionization technology II: GC-APCI/Q/ToF MS (APGC/HRMS) technology for ionization of steroids
Authors
손정현김소희차은주김호준우지혜최보경김승경권오승이재익
Issue Date
2012-08
Publisher
한국질량분석학회 2012여름정기학술대회
Abstract
The determination of anabolic steroids is generally performed by gas chromatography-mass spectrometry (GC-MS) with a high chromatographic resolution and electron impact (EI) ionization. But, the EI ionization gives rise to the extensive fragment ions resulting in the absence of the molecular ion as hard ionization technique. The extensive EI fragmentation causes the absence of characteristic ions and thus could be a serious drawback in doping control analysis. In this study, to overcome the these problems by GC-EI/MS, we report new ionization and analytical technology for the determination of trimethylsilyl (TMS) derivatized steroids using gas chromatography coupled with atmospheric pressure chemical ionization (APCI) and high resolution tandem mass spectrometry. The sensitivity, reproducibility and linearity were evaluated in the human urine sample. The results revealed that the present GC-APCI/HRMS system and analytical method are suitable for identification of anabolic steroids in human urine for doping control.
URI
http://pubs.kist.re.kr/handle/201004/42967
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KIST Publication > Conference Paper
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