Anti-Obesity and Hypolipidemic Effects of Rheum undulatum in High-Fat Diet-fed C57BL/6 mice through Protein Tyrosine Phosphatase 1B inhibition
- Anti-Obesity and Hypolipidemic Effects of Rheum undulatum in High-Fat Diet-fed C57BL/6 mice through Protein Tyrosine Phosphatase 1B inhibition
- 이우정; 윤구; 황예란; 김용기; 김수남
- chrysophanol; obesity; physcion; PTP1B; Rheum undulatum
- Issue Date
- BMB REPORTS
- VOL 45, NO 3, 141-146
- Protein tyrosine phosphatase 1B (PTP1B) is important in the regulation
of metabolic diseases and has emerged as a promising signaling
target. Previously, we reported the PTP1B inhibitory activity
of Rheum undulatum (RU). In the present study, we investigated
the metabolic regulatory effects of RU in a high-fat diet
(HFD) model. RU treatment significantly blocked body weight
gain, which was accompanied by a reduction of feed efficiency.
In addition, it led to a reduction of liver weight mediated by overexpression
of PPARα and CPT1 in the liver, and an increase in the
expression of adiponectin, aP2, and UCP3 in adipose tissue responsible
for the reduction of total and LDL-cholesterol levels.
Chrysophanol and physcion from RU significantly inhibited
PTP1B activity and strongly enhanced insulin sensitivity.
Altogether, our findings strongly suggest that 2 compounds are
novel PTP1B inhibitors and might be considered as anti-obesity
agents that are effective for suppressing body weight gain and improving
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