Spirobacillenes A and B, Unusual Spiro-cyclopentenones from Lysinibacillus fusiformis KMC003
- Spirobacillenes A and B, Unusual Spiro-cyclopentenones from Lysinibacillus fusiformis KMC003
- 박현봉; 김영주; 이재균; 이강노; 권학철
- Natural Products; Spirobacillene; Spiro-cyclopenenone; Microorganism; Lysinibacillus; NO; ROS
- Issue Date
- Organic letters
- VOL 14, NO 19, 5002-5005
- Two previously unreported spiro-cyclopentenones, spirobacillenes A (1) and B (2), were isolated from the 24 h broth culture of Lysinibacillus
fusiformis KMC003 derived from acidic coal-mine drainage. The structures of 1 and 2 were elucidated by analyses of the NMR, HRFABMS, singlecrystal
X-ray diffraction crystallography, and circular dichroism (CD) spectral data. Compound 1 possessed moderate inhibitory activity against
the production of nitric oxide (NO) and reactive oxygen species (ROS).
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