Micro-pillar Patterns and Stiffness Effect on Cell Trans-Migration
- Micro-pillar Patterns and Stiffness Effect on Cell Trans-Migration
- 정규환; 양기석; 나경환; 박설경; 박수학; 윤의성; 김진석
- Issue Date
- The 27th International Technical Conference on Circuits/Systems, Computers and Communications
- A novel method to control NIH3T3 cell migration has
been reported using a micro-patterned polydimethylsiloxane
(PDMS) substrate. Here, we make pillars with different dimensions
to identify the most efficient size (i.e., the diameter and spacing) for
recognition and migration. We also fabricate PDMS substrates with
both pillars and cavities. On the upper side of the PDMS substrate,
only the center has pillars for cell recognition, while the
surrounding areas remain flat. We also chose the gradient stiffness
depending on the back side cavity. It is now known that NIH3T3
cell migration at the frontier between flat and micro-pillar
substrates shows that cell trans-migration through the micro-pillar
substrates depends on the spacing between the micro-pillars.
However, it is observed that when there is a cavity, NIH3T3 cells
are more likely to move to stiffer regions than to micro-pillars.
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