Micro-pillar Patterns and Stiffness Effect on Cell Trans-Migration

Title
Micro-pillar Patterns and Stiffness Effect on Cell Trans-Migration
Authors
정규환양기석나경환박설경박수학윤의성김진석
Issue Date
2012-07
Publisher
The 27th International Technical Conference on Circuits/Systems, Computers and Communications
Abstract
A novel method to control NIH3T3 cell migration has been reported using a micro-patterned polydimethylsiloxane (PDMS) substrate. Here, we make pillars with different dimensions to identify the most efficient size (i.e., the diameter and spacing) for recognition and migration. We also fabricate PDMS substrates with both pillars and cavities. On the upper side of the PDMS substrate, only the center has pillars for cell recognition, while the surrounding areas remain flat. We also chose the gradient stiffness depending on the back side cavity. It is now known that NIH3T3 cell migration at the frontier between flat and micro-pillar substrates shows that cell trans-migration through the micro-pillar substrates depends on the spacing between the micro-pillars. However, it is observed that when there is a cavity, NIH3T3 cells are more likely to move to stiffer regions than to micro-pillars.
URI
http://pubs.kist.re.kr/handle/201004/43199
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KIST Publication > Conference Paper
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