Isolation of Prenylated Isoflavonoids from Cudrania tricuspidata Fruits that Inhibit A2E Photooxidation
- Isolation of Prenylated Isoflavonoids from Cudrania tricuspidata Fruits that Inhibit A2E Photooxidation
- 메즈박; 이희주; 전제승; 정동화; 김철영
- Cudrania tricuspidata; prenylated isoflavonoids; online HPLC-ABTS+ system; A2E photooxidation; 6,8-diprenylorobol; pomiferin
- Issue Date
- Natural Product Sciences
- VOL 17, NO 3, 206-211
- High-performance liquid chromatography coupled to an online ABTS+-based assay (online HPLCABTS
+) system was used to determine the principal antioxidants in Cudrania tricuspidata fruits. Six prenylated
isoflavonoids (1 - 6) were isolated from C. tricuspidata fruits according to the online HPLC-ABTS+ system. The
structures of isolated compounds, alpiniumisoflavone (1), 6,8-diprenylorobol (2), 6,8-diprenylgenistein (3),
pomiferin (4), 4'-methylalpiniumisoflavone (5), and osajin (6) were identified by their retention time, UV spectra,
ESI-MS, and NMR data. Among these compounds, 6,8-diprenylorobol (2) and pomiferin (4) reduced A2E
photooxidation in a dose dependent manner.
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