Facilitated intracellular delivery of peptide-guided nanoparticles in tumor tissues

Title
Facilitated intracellular delivery of peptide-guided nanoparticles in tumor tissues
Authors
Jong-Ho KimSang Mun BaeMoon-Hee NaHyeri ShinYu Jin Yang민경현Ki Young Choi김광명Rang-Woon Park권익찬Byung-Heon LeeAllan S. HoffmanIn-San Kim
Keywords
Tumor targeting; Nanoparticles; Homing peptide; Cancer imaging; Cancer therapy
Issue Date
2012-02
Publisher
Journal of controlled release
Citation
VOL 157, NO 3, 493-499
Abstract
Macromolecular nanoparticles can extravasate and accumulate within tumor tissues via the passive targeting system, reflecting enhanced permeability and the retention effect. However, the unsatisfactory tumor therapeutic efficacy of the passive-targeting system, attributable to the retention of extravasated nanoparticles in the vicinity of tumor vessels, argues that a new system that facilitates intracellular delivery of nanoparticles within tumors is needed. Here, we developed hydrophobically modified glycol chitosan (HGC) nanoparticles conjugated with interleukin-4 receptor (IL-4R) binding peptides, termed I4R, and tested them in mice bearing IL-4R-positive tumors. These HGC-I4R nanoparticles exhibited enhanced IL-4R-dependent cellular uptake in tumors compared to nonconjugated nanoparticles, leading to better therapeutic and imaging efficacy. We conclude that I4R facilitates and enhances cellular uptake of nanoparticles in tumor tissues. This study suggests that the intracelluar uptake of nanoparticles in tumors is an essential factor to consider in designing nanoparticles for tumor-targeted drug delivery and imaging.
URI
http://pubs.kist.re.kr/handle/201004/43322
ISSN
01683659
Appears in Collections:
KIST Publication > Article
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