Tumor-homing poly-siRNA/glycol chitosan self-cross-linked nanoparticles for systemic siRNA delivery in cancer treatment

Title
Tumor-homing poly-siRNA/glycol chitosan self-cross-linked nanoparticles for systemic siRNA delivery in cancer treatment
Authors
이소진Myung Sook HuhSeung Young LeeSolki MinSeulki LeeHeebeom Koo추준욱이경은전혜성Yongseok Choi최귀원Youngro ByunSeo Young JeongKinam Park김광명권익찬
Keywords
antitumor agents; glycol chitosan; nanoparticles; siRNA delivery; poly-siRNA
Issue Date
2012-07
Publisher
Angewandte Chemie international edition
Citation
VOL 51, NO 29, 7203-7207
Abstract
In summary, we have shown that thiolated glycol chitosan can form stable nanoparticles with poly-siRNA through charge–charge interactions and self-cross-linking, simultaneously. This structure provided sufficient stability from nucleases while still allowing for mono-siRNA release in the cytosol upon systemic delivery of poly-siRNA. The stable nanostructure of psi-TGC especially enabled tumor-targeted delivery and quick uptake into tumor cells for efficient gene silencing. With this psi-TGC, we showed in vivo VEGF gene silencing and reduced angiogenesis in tumors by treating with small amounts of siRNA. Considering the current interest in siRNAs and the number of hurdles in their biomedical application, psi-TGC has great potential as an siRNAdelivery system for tumor therapy.
URI
http://pubs.kist.re.kr/handle/201004/43348
ISSN
14337851
Appears in Collections:
KIST Publication > Article
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