In vivo NIRF imaging of tumor targetability of nanosized liposomes in tumor-bearing mice

Title
In vivo NIRF imaging of tumor targetability of nanosized liposomes in tumor-bearing mice
Authors
이상민Seung-Young LeeSangjin Park류주희나진희Heebeom Koo이경은전혜성권익찬김광명Seo Young Jeong
Keywords
drug delivery systems; imaging; liposomes; PEGylation; tumor targeting
Issue Date
2012-06
Publisher
Macromolecular bioscience
Citation
VOL 12, NO 6, 849-856
Abstract
To optimize tumor targetability of nanosized liposomes for application as drug carriers, various liposomes are prepared by incorporating different amounts (10, 30, and 50 wt%) of cationic, anionic, and PEGylated lipids into neutral lipid. In vivo near-infrared fluorescence images reveal that PEG-PE/PC liposomes display high tumor accumulation in tumor-bearing mice, while large amounts of DOTAP/PC liposomes are rapidly captured in the liver, resulting in poor tumor accumulation. These results demonstrate that optimization of the surface properties of liposomes is very important for their tumor targetability, and that in vivo imaging techniques are useful in developing and optimizing nanosized liposome-based drug carriers.
URI
http://pubs.kist.re.kr/handle/201004/43350
ISSN
16165187
Appears in Collections:
KIST Publication > Article
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