Tumor-targeting multi-functional nanoparticles for theragnosis: New paradigm for cancer therapy

Title
Tumor-targeting multi-functional nanoparticles for theragnosis: New paradigm for cancer therapy
Authors
류주희Heebeom Koo선인철Soon Hong Yuk최귀원김광명권익찬
Keywords
Theragnosis; Chemotherapy; Photodynamic therapy; siRNA therapy; Photothermal therapy; Optical imaging; Personalized medicine; Molecular imaging; Cancer; Nanomedicine
Issue Date
2012-10
Publisher
Advanced drug delivery reviews
Citation
VOL 64, NO 13, 1447-1458
Abstract
Theragnostic nanoparticles (NPs) contain diagnostic and therapeutic functions in one integrated system, enabling diagnosis, therapy, and monitoring of therapeutic response at the same time. For diagnostic function, theragnostic NPs require the inclusion of noninvasive imaging modalities. Among them, optical imaging has various advantages including sensitivity, real-time and convenient use, and non-ionization safety, which make it the leading technique for theragnostic NPs. For therapeutic function, theragnostic NPs have been applied to chemotherapy, photodynamic therapy, siRNA therapy and photothermal therapy. In this review, we present a recent progress reported in the development and applications of theragnostic NPs for cancer therapy. More specifically, we will focus on theragnostic NPs related with optical imaging, highlighting promising strategies based on optical imaging techniques.
URI
http://pubs.kist.re.kr/handle/201004/43352
ISSN
0169409X
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KIST Publication > Article
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