Tumor-targeting multi-functional nanoparticles for theragnosis: New paradigm for cancer therapy
- Tumor-targeting multi-functional nanoparticles for theragnosis: New paradigm for cancer therapy
- 류주희; Heebeom Koo; 선인철; Soon Hong Yuk; 최귀원; 김광명; 권익찬
- Theragnosis; Chemotherapy; Photodynamic therapy; siRNA therapy; Photothermal therapy; Optical imaging; Personalized medicine; Molecular imaging; Cancer; Nanomedicine
- Issue Date
- Advanced drug delivery reviews
- VOL 64, NO 13, 1447-1458
- Theragnostic nanoparticles (NPs) contain diagnostic and therapeutic functions in one integrated system, enabling
diagnosis, therapy, and monitoring of therapeutic response at the same time. For diagnostic function,
theragnostic NPs require the inclusion of noninvasive imaging modalities. Among them, optical imaging has
various advantages including sensitivity, real-time and convenient use, and non-ionization safety, which
make it the leading technique for theragnostic NPs. For therapeutic function, theragnostic NPs have been applied
to chemotherapy, photodynamic therapy, siRNA therapy and photothermal therapy. In this review, we
present a recent progress reported in the development and applications of theragnostic NPs for cancer therapy.
More specifically, we will focus on theragnostic NPs related with optical imaging, highlighting promising
strategies based on optical imaging techniques.
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