Phthalocyanine-aggregated polymeric nanoparticles as tumor-homing near-infrared absorbers for photothermal therapy of cancer

Title
Phthalocyanine-aggregated polymeric nanoparticles as tumor-homing near-infrared absorbers for photothermal therapy of cancer
Authors
Chang-Keun LimJiyoung Shin이용덕Jungahn KimKeun Sang OhSoon Hong YukSeo Young Jeong권익찬김세훈
Keywords
Phototermal therapy; Phthalocyanine; Near-infrared photonics; Tumor targeting; Hyperthermia; Nanoparticles
Issue Date
2012-09
Publisher
Theranostics
Citation
VOL 2, NO 9, 871-879
Abstract
Phthalocyanine-aggregated Pluronic nanoparticles were constructed as a novel type of near-infrared (NIR) absorber for photothermal therapy. Tiny nanoparticles (~ 60 nm, FPc NPs) were prepared by aqueous dispersion of phthalocyanine-aggregated self-assembled nanodomains that were phase-separated from the melt mixture with Pluronic. Under NIR laser irradiation, FPc NPs manifested robust heat generation capability, superior to an indi-vidual cyanine dye and cyanine-aggregated nanoparticles. Micro- and macroscopic imaging experiments showed that FPc NPs are capable of internalization into live cancer cells as well as tumor accumulation when intravenously administered into living mice. It is shown here that continuous NIR irradiation of the tumor-targeted FPc NPs can cause phototherapeutic effects in vitro and in vivo through excessive local heating, demonstrating potential of phthalocya-nine-aggregated nanoparticles as an all-organic NIR nanoabsorber for hyperthermia.
URI
http://pubs.kist.re.kr/handle/201004/43697
ISSN
18387640
Appears in Collections:
KIST Publication > Article
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