Antibody-conjugated TiO2 for Selective Photokilling of Target Bacteria

Antibody-conjugated TiO2 for Selective Photokilling of Target Bacteria
TiO2; bacteria; antibody; photokilling
Issue Date
2012년 한국생물공학회 추계학술대회
The titanium oxide (TiO2), photocatalyst, has been widely used in the field of environment for degradation of many air and water pollutants. Additionally, TiO2 photocatalysis has been intensively carried out to inactivate microorganisms. However, traditional studies of TiO2 photocatalyst generally involved low antimicrobial activity and no selectivity for target microorganisms due to random attack of microorganisms. We established antimicrobial activity method of target microorganisms using antibody-conjugated TiO2 (TiO2-AbE). To prepare for TiO2-AbE we were combined bacteria-specific antibody using via EDC/NHS with PAA coated TiO2 particles. We evaluated selective and efficient antimicrobial effect of TiO2-AbE with target E. coli, and compared with the non-specific other bacteria. The results clearly showed that the effect of TiO2-AbE on antimicrobial activity to E. coli was much greater than raw TiO2 particles while other bacteria were no significant differences between raw TiO2 and TiO2-AbE. The TiO2-AbE allows selective E. coli killing with low concentrations and short UV irradiation time compared to raw TiO2 particles. This method might be used to remove selective target bacteria for very short time and prevent infection of various bacteria.
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