Polymeric Conjugates for Drug Delivery

Title
Polymeric Conjugates for Drug Delivery
Authors
Nate LarsonHamid Ghandehari
Keywords
polymer-drug conjugates; polymer therapeutics; polymeric prodrugs; nanomedicine; bioconjugation; drug delivery
Issue Date
2012-01
Publisher
Chemistry of materials
Citation
VOL 24, 840-856
Abstract
The field of polymer therapeutics has evolved over the past decade and has resulted in the development of polymer−drug conjugates with a wide variety of architectures and chemical properties. Whereas traditional nondegradable polymeric carriers such as poly(ethylene glycol) (PEG) and N- (2-hydroxypropyl)methacrylamide (HPMA) copolymers have been translated to use in the clinic, functionalized polymer− drug conjugates are increasingly being utilized to obtain biodegradable, stimuli-sensitive, and targeted systems in an attempt to further enhance localized drug delivery and ease of elimination. In addition, the study of conjugates bearing both therapeutic and diagnostic agents has resulted in multifunctional carriers with the potential to both “see and treat” patients. In this paper, the rational design of polymer−drug conjugates will be discussed, followed by a review of different classes of conjugates currently under investigation. The design and chemistry used for the synthesis of various conjugates will be presented with additional comments on their potential applications and current developmental status.
URI
http://pubs.kist.re.kr/handle/201004/43790
ISSN
08974756
Appears in Collections:
KIST Publication > Article
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