Amphiphilic hyaluronic acid-based nanoparticles for tumor-specific optical/MR dual imaging
- Amphiphilic hyaluronic acid-based nanoparticles for tumor-specific optical/MR dual imaging
- 이동은; 김아영; 윤홍열; 최기영; 권익찬; 정서영; 박재형; 김광명
- Issue Date
- Journal of materials chemistry
- VOL 22, NO 21, 10444-10447
- The amphiphilic hyaluronic acid–5b-cholanic acid (HA–CA)
conjugates were synthesized to fabricate near-infrared fluorescence
(NIRF) dye conjugated and water-dispersible SPION-encapsulated
hyaluronic acid nanoparticles (HNPs) for a tumor-targeted optical
and magnetic resonance (MR) dual imaging contrast agent.
Notably, HNPs were preferentially accumulated in the tumor
region, implying that the hydrophilic HA shells of nanoparticles
allow prolonged circulation and excellent active targeting of the
SPION encapsulated nanoparticles in tumor-bearing mice.
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