Amphiphilic hyaluronic acid-based nanoparticles for tumor-specific optical/MR dual imaging

Title
Amphiphilic hyaluronic acid-based nanoparticles for tumor-specific optical/MR dual imaging
Authors
이동은김아영윤홍열최기영권익찬정서영박재형김광명
Issue Date
2012-06
Publisher
Journal of materials chemistry
Citation
VOL 22, NO 21, 10444-10447
Abstract
The amphiphilic hyaluronic acid–5b-cholanic acid (HA–CA) conjugates were synthesized to fabricate near-infrared fluorescence (NIRF) dye conjugated and water-dispersible SPION-encapsulated hyaluronic acid nanoparticles (HNPs) for a tumor-targeted optical and magnetic resonance (MR) dual imaging contrast agent. Notably, HNPs were preferentially accumulated in the tumor region, implying that the hydrophilic HA shells of nanoparticles allow prolonged circulation and excellent active targeting of the SPION encapsulated nanoparticles in tumor-bearing mice.
URI
http://pubs.kist.re.kr/handle/201004/43813
ISSN
09599428
Appears in Collections:
KIST Publication > Article
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