Astrocytes as GABA-ergic and GABA-ceptive Cells

Title
Astrocytes as GABA-ergic and GABA-ceptive Cells
Authors
윤보은우준성이창준
Keywords
Astrocyte; Glial GABA; Tonic inhibition
Issue Date
2012-11
Publisher
Neurochemical research
Citation
VOL 37, NO 11, 2474-2479
Abstract
GABA (gamma-aminobutyric acid) is considered to be the major inhibitory neurotransmitter that is synthesized in and released from GABA-ergic neurons in the brain. However, recent studies have shown that not only neurons but astrocytes contain a considerable amount of GABA, which can be released and activate the receptors responsive to GABA. In addition, astrocytes are themselves responsive to GABA by expressing GABA receptors. These exciting new findings raise more questions about the origin of GABA, whether it is synthesized or taken up, and about the role of astrocytic GABA and GABA receptors. In this review, we propose several potential pathways for astrocytes to accumulate GABA and discuss the evidence for functional expression of GABA receptors in astrocytes.
URI
http://pubs.kist.re.kr/handle/201004/43826
ISSN
03643190
Appears in Collections:
KIST Publication > Article
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