Synthesis and Antiproliferative Activity of New Aminoisoquinolinylurea Derivatives against Melanoma Cell Line

Title
Synthesis and Antiproliferative Activity of New Aminoisoquinolinylurea Derivatives against Melanoma Cell Line
Authors
조혜정모하메드엘가말오창현이소하김가람홍준희최홍석유경호
Keywords
A375P; Aminoisoquinoline; Anticancer; Diarylurea; Melanoma
Issue Date
2012-11
Publisher
Bulletin of the Korean Chemical Society
Citation
VOL 33, NO 11, 3635-3639
Abstract
A series of new diarylureas possessing aminoisoquinoline scaffold was synthesized, and their in vitro antiproliferative activity against A375P human melanoma cell line was tested. Compounds 1d, 1l, 1n, 1p, 1q, and 1t showed superior potency against A375P to Sorafenib. The highest potency was shown by compound 1p possessing 3,5-bis(trifluoromethyl)phenyl terminal ring with IC50 value of 0.41 μM.
URI
http://pubs.kist.re.kr/handle/201004/43827
ISSN
02532964
Appears in Collections:
KIST Publication > Article
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