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dc.contributor.author조혜정-
dc.contributor.author모하메드엘가말-
dc.contributor.author오창현-
dc.contributor.author이소하-
dc.contributor.author김가람-
dc.contributor.author홍준희-
dc.contributor.author최홍석-
dc.contributor.author유경호-
dc.date.accessioned2015-12-03T00:53:47Z-
dc.date.available2015-12-03T00:53:47Z-
dc.date.issued201211-
dc.identifier.citationVOL 33, NO 11, 3635-3639-
dc.identifier.issn02532964-
dc.identifier.other38458-
dc.identifier.urihttp://pubs.kist.re.kr/handle/201004/43827-
dc.description.abstractA series of new diarylureas possessing aminoisoquinoline scaffold was synthesized, and their in vitro antiproliferative activity against A375P human melanoma cell line was tested. Compounds 1d, 1l, 1n, 1p, 1q, and 1t showed superior potency against A375P to Sorafenib. The highest potency was shown by compound 1p possessing 3,5-bis(trifluoromethyl)phenyl terminal ring with IC50 value of 0.41 μM.-
dc.publisherBulletin of the Korean Chemical Society-
dc.subjectA375P-
dc.subjectAminoisoquinoline-
dc.subjectAnticancer-
dc.subjectDiarylurea-
dc.subjectMelanoma-
dc.titleSynthesis and Antiproliferative Activity of New Aminoisoquinolinylurea Derivatives against Melanoma Cell Line-
dc.typeArticle-
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