Efficient Functional Delivery of siRNA using Mesoporous Silica Nanoparticles with Ultralarge Pores

Title
Efficient Functional Delivery of siRNA using Mesoporous Silica Nanoparticles with Ultralarge Pores
Authors
Hee-Kyung NaMi-Hee KimKihyun ParkSoo-Ryoon Ryoo이경은전혜성Ryong RyooChangbong HyeonDal-Hee Min
Keywords
cancer therapy; drug delivery; mesoporous materials; nanoparticles; RNA interference
Issue Date
2012-06
Publisher
Small
Citation
VOL 8, NO 11, 1752-1761
Abstract
Among various nanoparticles, mesoporous silica nanoparticles (MSNs) have attracted extensive attention for developing efficient drug-delivery systems, mostly due to their high porosity and biocompatibility. However, due to the small pore size, generally below 5 nm in diameter, potential drugs that are loaded into the pore have been limited to small molecules. Herein, a small interfering RNA (siRNA) delivery strategy based on MSNs possessing pores with an average diameter of 23 nm is presented. The siRNA is regarded as a powerful gene therapeutic agent for treatment of a wide range of diseases by enabling post-transcriptional gene silencing, so-called RNA interference. Highly efficient, sequence-specific, and technically very simple target gene knockdown is demonstrated using MSNs with ultralarge pores of size 23 nm in vitro and in vivo without notable cytotoxicity.
URI
http://pubs.kist.re.kr/handle/201004/43842
ISSN
16136810
Appears in Collections:
KIST Publication > Article
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