Sex differences in amygdala subregions: Evidence from subregional shape analysis
- Sex differences in amygdala subregions: Evidence from subregional shape analysis
- Hengjun J. Kim; 김남국; 김세현; 홍석준; 박경모; 임사비나; 박정미; 나병조; 채윤병; 이정찬; 여수정; 최일환; 조승연; 조경구
- amygdala; Sex difference; difference; Centromedial nucleus; Superficial nucleus; Aging
- Issue Date
- VOL 60, NO 4, 2054-2061
- Each subregion of the amygdala is characterized by a distinct cytoarchitecture and function. However, most
previous studies on sexual dimorphism and aging have assessed differences in the structure of the amygdala
at the level of the amygdala in its entirety rather than at the subregional level. Using an amygdala subregional
shape analysis, we investigated the effects of sex, age, and the sex×age interaction on the subregion after
controlling for intracranial volume. We found the main effect of age in the subregions and the effect of sex
in the superficial nucleus, which showed that men had a larger mean radius than women. We also found a
sex×age interaction in the centromedial nucleus, in that the radius of the centromedial nucleus showed a
steeper decline with age in women compared with men. Regarding the amygdala volume as a whole, we
found only an age effect and did not find any other significant difference between genders. The sex difference
in the amygdala subregion and its relevance to the circulating gonadal hormone were discussed.
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