18F-FDG PET/CT for Detecting Distant Metastases in Patients With Recurrent Head and Neck Squamous Cell Carcinoma

Title
18F-FDG PET/CT for Detecting Distant Metastases in Patients With Recurrent Head and Neck Squamous Cell Carcinoma
Authors
이종석김재성이정현최승호남순열김상윤노종렬
Keywords
fluorine 18-fluorodeoxyglucose; positron emission tomography/computed tomography; distant metastases; recurrent squamous cell carcinoma; head and neck; PET/CT
Issue Date
2012-11
Publisher
Journal of surgical oncology
Citation
VOL 106, NO 6, 708-712
Abstract
Background: Distant metastases (DMs) increase in patients with recurrent head and neck squamous cell carcinoma (HNSCC). We evaluated the ability of fluorine 18-fluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) to detect DMs in these patients. Method: We evaluated 82 consecutive patients with histologically confirmed recurrent HNSCC. Patients with previous DMs were excluded. All patients received whole-body 18F-FDG PET/CT scanning for restaging of recurrent HNSCC and follow-up after salvage surgery. Any suspected DMs were confirmed by histology and further imaging workups. The diagnostic ability of 18F-FDG PET/CT to detect DMs was assessed. Results: Of the 82 patients, 14 (17%) had DMs. The lung (93%) and bone (43%) were the most frequent metastatic sites. 18F-FDG PET/CT correctly diagnosed the presence of DMs in 12 of 14 patients and their absence in 57 of 68 patients. The sensitivity, specificity, accuracy, and positive (PPV) and negative predictive values (NPV) of 18F-FDG PET/CT for detecting DMs were 86% (95% confidence interval, 57–98%), 84% (72–91%), 84% (74–91%), 52% (30–73%), and 97% (88–99%), respectively. Conclusions: 18F-FDG PET/CT may be useful in the detection of DMs prior to and after salvage surgery in the high-risk patients with recurrent HNSCC.
URI
http://pubs.kist.re.kr/handle/201004/43858
ISSN
00224790
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KIST Publication > Article
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