Extracellular low pH modulates phosphatidylserine-dependent phagocytosis in macrophages by increasing stabilin-1 expression

Title
Extracellular low pH modulates phosphatidylserine-dependent phagocytosis in macrophages by increasing stabilin-1 expression
Authors
박승윤배동준김민진Mei Lan Piao김인산
Issue Date
2012-03
Publisher
The Journal of biological chemistry
Citation
VOL 287, NO 14, 11261-11271
Abstract
Background: Extracellular acidification is a feature of inflammation loci in which apoptotic cell clearance is necessary for inflammation resolution. Results: Low pH increases stabilin-1 expression and stabilin-1-mediated phagocytosis in macrophages. Conclusion: Extracellular acidification up-regulates stabilin-1 expression in macrophages, thereby modulating the phagocytic capacity of macrophages. Significance: This study should help elucidate the molecular mechanism regarding stabilin-1 regulation and apoptotic cell clearance in acidic environments.
URI
http://pubs.kist.re.kr/handle/201004/43862
ISSN
00219258
Appears in Collections:
KIST Publication > Article
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