Efficient Separation and Quantitative Analysis of Coronary Artery Disease Biomarkers

Title
Efficient Separation and Quantitative Analysis of Coronary Artery Disease Biomarkers
Authors
박호영최종훈이관희
Keywords
Magnetic Bead; Coronary Artery Disease; C-reactive Protein
Issue Date
2012-10
Publisher
Biomedical Engineering Society (BMES)
Abstract
Coronary artery disease (CAD) stands atop the causes of mortality throughout the world1. Mainly responsible for its notoriety is its difficult diagnosis, as arterial plaque responsible for CAD develops over a time frame of decades before other symptoms are manifested. Such diagnostic struggles consequently lead to arterial plaque rupture. Due to the rapid degeneration of CAD patients post-rupture, it is crucial that the detection of pre-rupture CAD biomarkers be sensitive enough to detect trace amounts, and be specific enough to isolate them from other undesired markers. We hypothesize that superparamagnetic colloidal-crystallized magnetic nanoparticles (CCNPs) with good water dispersity can be used to detect and separate C-reactive protein (CRP) and sCD40L, CAD biomarkers.
URI
http://pubs.kist.re.kr/handle/201004/43868
Appears in Collections:
KIST Publication > Conference Paper
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