The Array of Nanowells to Characterize Interactions Between Individual Human Mesenchymal Stem Cells and T Cells
- The Array of Nanowells to Characterize Interactions Between Individual Human Mesenchymal Stem Cells and T Cells
- 최종훈; 황민태; David Chesler; Alfredo Quinones-Hinojosa; Christopher Love; 이관희
- Mesenchymal Stem Cell; T Cells; Microarray; Nanoarray; Immunology; Stem cell
- Issue Date
- Nano Korea 2012
- Mesenchymal stem cell (MSC) based immune therapy has been identified as a potential alternative treatment for these diseases. Instead of knocking down body’s immune functions, it has the potential targets specifically on the inflammation site, and its immunomodulation effect may help the immune system to re-achieve its balance in a non-toxic manner. So far, there has been no agreement regarding how MSCs could suppress T cell functions. One of the major debates is whether cell-to-cell contact is required in order for MSCs to exert their functions or whether the soluble factor mechanism is sufficient alone. One of the major difficulties in studying MSCs is their highly heterogeneous nature even in the same culture. The bulk assays studying a group of cells would not provide information about individual contributions from each cell that may take a critical role in responses. To address this problem fully, we studied MSC and CD4+ T cell interaction at a single cell level. This way, we were able to examine how individual MSCs interact with CD4+ T cells and the factors causing the differences in their behavior.
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