The association between some endocrine disruptors and hypospadias in biological samples
- The association between some endocrine disruptors and hypospadias in biological samples
- 최해민; JOOHOON KIM; YEONGJAE IM; SANGHOUCK LEE; 김연제
- endocrine disruptors; hypospadias; hypopadias; association; biological sample; phthalate; alkylphenol; bisphenol A
- Issue Date
- Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering
- VOL 47, NO 13, 2173-2179
- Hypospadias is a birth defect found in boys in which the urinary tract opening is not at the tip of the penis. The etiology of
hypospadias is still unidentified, but endocrine disruptors are considered as one possible cause of hypospadias. In this study, target
endocrine disruptor compoundswere established for an assay. The target compounds included 5 phthalates (di-(2-ethylhexyl)phthalate
(DEHP), di-n-butyl-phthalate (DBP), mono-(2- ethylhexyl) phthalate (MEHP), mono-n-butyl-phthalate (MBP) and phthalic acid
(PA)), 2 alkylphenols (n-nonylphenol (n-NP) and t-octylphenol (t-OP)) and bisphenol A. The association between these 8 endocrine
disruptors and hypospadias was studied. The levels of endocrine disruptors in the urine and plasma of a control group were compared
with those of a patient group. DEHP (P = 0.006) and n-NP (P = 7.26e-6) in the urine samples and PA (P = 0.009) and BPA (P =
7.22e-10) in the plasma samples showed a significant association with hypospadias. The levels of endocrine disruptors in the urine
and plasma of the mothers were also compared to those of the patients to investigate the metastasis of the endocrine disruptors from
the mother. These levels did not, however, show a relationship with hypospadias (R2 = 0.001–0.563).
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