M13 Phage-Functionalized Single-Walled Carbon Nanotubes As Nanoprobes for Second Near-Infrared Window Fluorescence Imaging of Targeted Tumors
- M13 Phage-Functionalized Single-Walled Carbon Nanotubes As Nanoprobes for Second Near-Infrared Window Fluorescence Imaging of Targeted Tumors
- 이현정; Debadyuti Ghosh; 함문호; Jifa Qi; Paul Barone; Michael S. Strano; Angela M. Belcher
- Nano probes; Single-walled carbon nanotubes; second NIR window fluorescence; medical imaging; targeted imaging; molecular imaging; hybrid imaging probes; nanobiotechnology
- Issue Date
- Nano letters
- VOL 12, NO 3, 1176-1183
- Second near-infrared (NIR) window light (950−1400 nm) is attractive for in vivo fluorescence imaging due to its
deep penetration depth in tissues and low tissue autofluorescence. Here we show genetically engineered multifunctional M13
phage can assemble fluorescent single-walled carbon nanotubes (SWNTs) and ligands for targeted fluorescence imaging of
tumors. M13-SWNT probe is detectable in deep tissues even at a low dosage of 2 μg/mL and up to 2.5 cm in tissue-like
phantoms. Moreover, targeted probes show specific and up to 4-fold improved uptake in prostate specific membrane antigen
positive prostate tumors compared to control nontargeted probes. This M13 phage-based second NIR window fluorescence
imaging probe has great potential for specific detection and therapy monitoring of hard-to-detect areas.
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