M13 Phage-Functionalized Single-Walled Carbon Nanotubes As Nanoprobes for Second Near-Infrared Window Fluorescence Imaging of Targeted Tumors

Title
M13 Phage-Functionalized Single-Walled Carbon Nanotubes As Nanoprobes for Second Near-Infrared Window Fluorescence Imaging of Targeted Tumors
Authors
이현정Debadyuti Ghosh함문호Jifa QiPaul BaroneMichael S. StranoAngela M. Belcher
Keywords
Nano probes; Single-walled carbon nanotubes; second NIR window fluorescence; medical imaging; targeted imaging; molecular imaging; hybrid imaging probes; nanobiotechnology
Issue Date
2012-03
Publisher
Nano letters
Citation
VOL 12, NO 3, 1176-1183
Abstract
Second near-infrared (NIR) window light (950−1400 nm) is attractive for in vivo fluorescence imaging due to its deep penetration depth in tissues and low tissue autofluorescence. Here we show genetically engineered multifunctional M13 phage can assemble fluorescent single-walled carbon nanotubes (SWNTs) and ligands for targeted fluorescence imaging of tumors. M13-SWNT probe is detectable in deep tissues even at a low dosage of 2 μg/mL and up to 2.5 cm in tissue-like phantoms. Moreover, targeted probes show specific and up to 4-fold improved uptake in prostate specific membrane antigen positive prostate tumors compared to control nontargeted probes. This M13 phage-based second NIR window fluorescence imaging probe has great potential for specific detection and therapy monitoring of hard-to-detect areas.
URI
http://pubs.kist.re.kr/handle/201004/43924
ISSN
15306984
Appears in Collections:
KIST Publication > Article
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