Ethanol-Dispersed Polymer Nanofi bers as a Highly Selective Cell Isolation and Release Platform for CD4 + T Lymphocytes
- Ethanol-Dispersed Polymer Nanofi bers as a Highly Selective Cell Isolation and Release Platform for CD4 + T Lymphocytes
- 전승현; 김광희; 안효진; 김병찬; 손정희; 김미주; 도준상; Yee, Cassian; 이경미; 김중배
- Nanofiber; Receptor; CD4+T Lymphocytes; Isolation; Release
- Issue Date
- Advanced functional materials
- VOL 22, NO 21, 4448-4455
- A novel cell isolation and release platform using electrospun polystyrenepoly(
styrene- co -maleic anhydride) (PS-PSMA) nanofi bers is presented.
Ethanol treatment of PS-PSMA nanofi bers, employed for the purpose of
sterilization, signifi cantly increases their inter-fi ber space for both antibody
conjugation and subsequent cell separation. For the selective isolation of
CD4 + T cells from heterogeneous mixtures of mouse lymph nodes, capture
effi ciencies of up to 100% are achieved while maintaining cellular integrity
and viability. Once captured, CD4 + T lymphocytes can also be released from
the NF scaffolds, further demonstrating its potential functionality as an
immune cell-supporting and releasing matrix. This is the fi rst demonstration
of lymphocyte-culture scaffolds enabling selective isolation, accommodation,
and sustained release of CD4 + T cells for the purpose of cell therapies.
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