Effect of two-step sintering on optical transmittance and mechanical strength of polycrystalline alumina ceramics

Title
Effect of two-step sintering on optical transmittance and mechanical strength of polycrystalline alumina ceramics
Authors
김형수김영도김상우
Keywords
Transparent alumina; mechanical strength; optical transmittance; two-step sintering; Ceramics; Polycrystalline
Issue Date
2012-10
Publisher
Advances in Sintering Science and Technology II: Ceramic Transactions
Citation
VOL 232, 185-192
Abstract
To obtain selective and potent inhibitor for T-type calcium channel by ligand based drug design, 4-piperidinecarboxylate and 4-piperidinecyanide derivatives were prepared and evaluated for in vitro and in vivo activity against a1G calcium channel. Among them, several compounds showed good T-type calcium channel inhibitory activity and minimal off-target activity over hERG channel (% inhibition at 10 lM = 61.85–71.99, hERG channel IC50 = 1.57 ± 0.14–4.98 ± 0.36 lM). Selected compound 31a was evaluated on SNL model of neuropathic pain and showed inhibitory effect on mechanical allodynia.
URI
http://pubs.kist.re.kr/handle/201004/43948
Appears in Collections:
KIST Publication > ETC
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