Effect of two-step sintering on optical transmittance and mechanical strength of polycrystalline alumina ceramics
- Effect of two-step sintering on optical transmittance and mechanical strength of polycrystalline alumina ceramics
- 김형수; 김영도; 김상우
- Transparent alumina; mechanical strength; optical transmittance; two-step sintering; Ceramics; Polycrystalline
- Issue Date
- Advances in Sintering Science and Technology II: Ceramic Transactions
- VOL 232, 185-192
- To obtain selective and potent inhibitor for T-type calcium channel by ligand based drug design, 4-piperidinecarboxylate
and 4-piperidinecyanide derivatives were prepared and evaluated for in vitro and
in vivo activity against a1G calcium channel. Among them, several compounds showed good T-type calcium
channel inhibitory activity and minimal off-target activity over hERG channel (% inhibition at
10 lM = 61.85–71.99, hERG channel IC50 = 1.57 ± 0.14–4.98 ± 0.36 lM). Selected compound 31a was
evaluated on SNL model of neuropathic pain and showed inhibitory effect on mechanical allodynia.
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