Nanophotosensitizers toward advanced photodynamic therapy of Cancer

Title
Nanophotosensitizers toward advanced photodynamic therapy of Cancer
Authors
임창근허정윤신승훈정근수서영훈장우동박종래박수영김세훈권익찬
Keywords
Photodynamic therapy; Photosensitizer; Nanomedicine; Nanotherapeutics
Issue Date
2013-07
Publisher
Cancer letters
Citation
VOL 334, NO 2, 176-187
Abstract
Photodynamic therapy (PDT) is a non-invasive treatment modality for selective destruction of cancer and other diseases and involves the colocalization of light, oxygen, and a photosensitizer (PS) to achieve photocytotoxicity. Although this therapeutic method has considerably improved the quality of life and life expectancy of cancer patients, further advances in selectivity and therapeutic efficacy are required to overcome numerous side effects related to classical PDT. The application of nanoscale photosensitizers (NPSs) comprising molecular PSs and nanocarriers with or without other biological/photophysical functions is a promising approach for improving PDT. In this review, we focus on four nanomedical approaches for advanced PDT: (1) nanocarriers for targeted delivery of PS, (2) introduction of active targeting moieties for disease-specific PDT, (3) stimulus-responsive NPSs for selective PDT, and (4) photophysical improvements in NPS for enhanced PDT efficacy.
URI
http://pubs.kist.re.kr/handle/201004/43952
ISSN
03043835
Appears in Collections:
KIST Publication > ETC
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