Nanophotosensitizers toward advanced photodynamic therapy of Cancer
- Nanophotosensitizers toward advanced photodynamic therapy of Cancer
- 임창근; 허정윤; 신승훈; 정근수; 서영훈; 장우동; 박종래; 박수영; 김세훈; 권익찬
- Photodynamic therapy; Photosensitizer; Nanomedicine; Nanotherapeutics
- Issue Date
- Cancer letters
- VOL 334, NO 2, 176-187
- Photodynamic therapy (PDT) is a non-invasive treatment modality for selective destruction of cancer and
other diseases and involves the colocalization of light, oxygen, and a photosensitizer (PS) to achieve
photocytotoxicity. Although this therapeutic method has considerably improved the quality of life and
life expectancy of cancer patients, further advances in selectivity and therapeutic efficacy are required
to overcome numerous side effects related to classical PDT. The application of nanoscale photosensitizers
(NPSs) comprising molecular PSs and nanocarriers with or without other biological/photophysical
functions is a promising approach for improving PDT. In this review, we focus on four nanomedical
approaches for advanced PDT: (1) nanocarriers for targeted delivery of PS, (2) introduction of active
targeting moieties for disease-specific PDT, (3) stimulus-responsive NPSs for selective PDT, and (4)
photophysical improvements in NPS for enhanced PDT efficacy.
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