A study on the constituents of Chrysanthemum indicum L. and their inhibitory effect on recombinant human aldose reductase
- A study on the constituents of Chrysanthemum indicum L. and their inhibitory effect on recombinant human aldose reductase
- 이은하; 이주영; 최순정; 조형; 판철호; 정상훈
- Chrysanthemum indicum L.; recombinant human aldose reductase; diabetic complications; Sudachitin
- Issue Date
- International Biotechnology Symposium (IBS) and Exhibition
- The key enzyme in the polyol pathway, aldose reductase, catalyzes the NADPH-dependent conversion of glucose to sorbitol and it has been reported to play an important role in the pathogenesis of diabetic complications.
This study is to see whether Chrysanthemum indicum L. has inhibitory effect on aldose reductase. Four flavonoids sudachitin (1), hesperetin (2), chrysoeriol (3), and acacetin (4) were isolated from methylene chloride fraction of C. indicum L. and the structures of all compounds were established on the basis of spectroscopic analysis and chemical evidence. Sudachitin (1) was isolated for the first time from this plant.
The isolated compounds were tested for their inhibitory effect on recombinant human aldose reductase. All the compounds (1-4) exhibited moderate activity against recombinant human aldose reductase in vitro. These results suggest that C. indicum L. could be used as a nutraceutical for the alleviation of diabetic complications.
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