Synthesis of Stimuli-Responsive PEO-Based Triblock Copolymers and Their Applications for Preparation of Iron Oxide Nanoparticles
- Synthesis of Stimuli-Responsive PEO-Based Triblock Copolymers and Their Applications for Preparation of Iron Oxide Nanoparticles
- 남주현; 최우석; 이재혁; 권난현; 강호중; 이재열; 김세훈; 김정안
- water-soluble triblock copolymers; RAFT radical copolymerization; PEO-based RAFT agent; phase transition
behavior; iron oxide nanoparticles
- Issue Date
- Macromolecular research
- VOL 20, NO 11, 1173-1180
- In this paper, the important and useful method for manufacturing superparamagnetic iron oxide nanoparticles
stabilized by water-soluble poly(ethylene oxide) (PEO)-based triblock copolymers showing stimuli-responsive
phase transition is introduced. Triblock copolymers, such as poly(ethylene oxide-b-N-vinylimidazole-b-3-
(methacrylamino)phenylboronic acid) (PEO-b-PVIm-b-PMAPBA), poly(ethylene oxide-b-N-vinylpyrrolidone-b-
3-(methacrylamino)phenylboronic acid) (PEO-b-PVP-b-PMAPBA), and poly(ethylene oxide-b-N-vinylimidazoleb-
maleic acid) (PEO-b-PVIm-b-PMAc), were synthesized using the sequential monomer addition method via
reversible addition fragmentation chain transfer (RAFT) radical block copolymerizations of the corresponding
monomers, using PEO-based RAFT agent. After complete polymerization of N-vinylimidazole or N-vinylpyrrolidone
in dimethylformamide (DMF) at 110 ℃, 3-(methacrylamino)phenylboronic acid (MAPBA) was polymerized
in DMF at 90 ℃ for 24 h, and N-phenylmaleimide was polymerized in dimethylsulfoxide (DMSO) at 110 ℃ for 28 h.
All the block copolymers were water-soluble and efficient enough to stabilize the surface of nano-sized iron oxide
particles in water. The nanoparticles were stable in neutral aqueous media for at least one month. The resulting products
were characterized by a combination of 1H nuclear magnetic resonance spectroscopy (NMR), size exclusion
chromatography, transmission electron microscopy (TEM), electron diffraction pattern, and phase transition behavior
of the block copolymers using UV/visible spectrophotometer.
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