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dc.contributor.author조형-
dc.contributor.author이희주-
dc.contributor.author김철영-
dc.contributor.author손진기-
dc.contributor.author정상훈-
dc.date.accessioned2015-12-03T00:54:14Z-
dc.date.available2015-12-03T00:54:14Z-
dc.date.issued201301-
dc.identifier.citationVOL 51, 231-241-
dc.identifier.issn02786915-
dc.identifier.other38653-
dc.identifier.urihttp://pubs.kist.re.kr/handle/201004/43992-
dc.description.abstractRetinal ganglion cells (RGCs) death caused by oxidative stress is a common risk factor for glaucoma. In the present study, 8-hydroxycalamenene was isolated from the hexane fraction of Reynoutria elliptica. We showed that 8-hydroxycalamenene attenuated the cell death of transformed RGC-5 cells. This compound also produced a dose-dependent decrease in the expression of apoptotic proteins (cleaved PARP and caspase- 3) induced by L-buthionine-(S,R)-sulfoximine (BSO) plus glutamate and stimulated glutathione and glutathione S-transferase activity. Moreover, the addition of 8-hydroxycalamenene to cell cultures restored the reduced mitochondrial membrane potential resulting from glutamate/BSO treatment. The presence of N-methyl-D-aspartate in the retina of rats affected the thickness of the inner plexiform layer (IPL) and increased the number of TUNEL-positive RGCs. However, 8-hydroxycalamenene protected against thinning of the IPL and reduced TUNEL-positive cells in the ganglion cell layer. Thus, 8-hydroxycalamenene isolated from R. elliptica exerts neuroprotective effects both in vitro and in vivo.-
dc.publisherFood and chemical toxicology-
dc.subjectReynoutria elliptica-
dc.subject8-Hydroxycalamenene-
dc.subjectNeuroprotection-
dc.subjectRGC-5-
dc.title8-Hydroxycalamenene isolated from the rhizomes of Reynoutria elliptica exerts neuroprotective effects both in vitro and in vivo-
dc.typeArticle-
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