MRI-monitored long-term therapeutic hydrogel system for brain tumors without surgical resection
- MRI-monitored long-term therapeutic hydrogel system for brain tumors without surgical resection
- 김장일; 김보라; 전창주; 이승훈; 송수창
- MRI-monitored long-term therapeutic; hydrogel; Imaging agents; Phosphazenes; Irinotecan; Brain tumors
- Issue Date
- VOL 33, NO 19, 4836-4842
- To overcome the unresolved issues of conventional therapeutic approaches such as radiation therapy,
chemotherapy, combinational chemotherapy, and surgical treatment, we designed an injectable ‘MRImonitored
long-term therapeutic hydrogel (MLTH)’ system as an alternative/adjuvant approach for brain
tumors. The MLTH system consists of a thermosensitive/magnetic poly(organophosphazene) hydrogel
(the magnetic hydrogel) as a biodegradable imaging platform and an anticancer drug as a therapeutic
agent via a simple physical mixing. The MLTH system has adequate properties for the MRI-monitored
long-term therapy as follows: injectability, localizability due to fast gelation at body temperature,
biocompatibility, biodegradability, sustained drug release, and MR imaging function. Since the MLTH
system only requires a very small-sized pin hole injected into the area of brain tumors stereotactically,
we suggest that the MLTH system can be an alternative/adjuvant approach to treat the malignant brain
tumors without any surgical resection. Furthermore, we expect that the MLTH system can minimize the
side effects from either an intravenous injection or surgical operation because one of the aims of MLTH is
to focus on the sustained local delivery of anticancer drugs via a one- or two-time intratumoral injections.
Thus, we assessed successfully the MRI-monitored long-term therapeutic potentialities of the
MLTH system for brain tumors and estimated the inhibition efficacy of tumor growth via an MRImonitored
long-term therapy in this study.
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