Injectable poly(organophosphazene)-camptothecin conjugate hydrogels: Synthesis, characterization, and antitumor activities

Title
Injectable poly(organophosphazene)-camptothecin conjugate hydrogels: Synthesis, characterization, and antitumor activities
Authors
조정교전창주구효정송수창
Keywords
Antitumor activity; Poly(organophosphazene); Thermosensitive hydrogel; Polymer?drug conjugate; Stability of camptothecin
Issue Date
2012-08
Publisher
European journal of pharmaceutics and biopharmaceutics
Citation
VOL 81, NO 3, 582-590
Abstract
The objective of this study is to develop an effective polymer therapeutics involving camptothecin (CPT) with enhanced efficacy and lessened systemic side-toxicity for cancer treatment. Polymer–CPT conjugates (PCCs), which consisted of CPT–20-glycinate and poly(organophosphazene) bearing carboxylic acid, were synthesized, characterized for physicochemical properties, in vitro degradation and CPT release behaviors from the PCC, and evaluated their anticancer activity. The aqueous solutions of all these PCCs showed a thermo-responsive sol–gel transition behavior for injectable application near room temperature. The CPT incorporated into the hydrogel was proven to be stable in vitro over 15 days. The in vitro cytotoxicity of the PCC was verified to be effective against four kinds of human cancer cell lines. The in vivo anticancer activity study with HT-29 colon cancer cell xenografted mice showed that the intratumorally injected PCC hydrogel inhibited the tumor growth more effectively relative to CPT alone ( 29% vs. 130% in tumor size).
URI
http://pubs.kist.re.kr/handle/201004/44007
ISSN
09396411
Appears in Collections:
KIST Publication > Article
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